Gene-by-Environment Interaction for Passive Smoking and Glutathione S-Transferase M1?
نویسندگان
چکیده
منابع مشابه
Gene-by-environment interaction for passive smoking and glutathione S-transferase M1?
In this issue of the Journal, a report by Bennett et al. (1) gives evidence for an interaction in never-smoking Missouri women between exposure to environmental tobacco smoke (ETS) and the homozygous null genotype for glutathione S-transferase (GST) M1 (GSTM1) in increasing the risk of lung cancer. Because GST enzymes act on certain carcinogenic constituents of tobacco smoke to make them excret...
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BACKGROUND It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma. METHODS A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GST...
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Nasopharyngeal carcinoma (NPC) is a serious health problem in Thailand. It is caused by the combined effects of Epstein-Barr virus (EBV), carcinogens and genetic susceptibility. The glutathione S-transferase M1 gene (GSTM1) encodes a phase II enzyme responsible for detoxifying carcinogenic electrophiles. Polymorphic null forms of the gene GSTM1 lack enzyme activity and have been associated with...
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Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1999
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/91.23.1985